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: The [[Active Site|active site]] is shaped to fit with only one [[Substrate (Biology)|substrate]] so [[enzyme]]s all have specific roles in an [[organism]].
: When an [[enzyme]] becomes [[denaturation|denatured]] the [[Substrate (Biology)|substrate]] can no longer fit into the '''active site''' preventing the [[enzyme]] from functioning.
===References===
====AQA====
:[https://www.amazon.co.uk/gp/product/1782946381/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1782946381&linkCode=as2&tag=nrjc-21&linkId=5ec5fc3f6429e30c1d9ab9bca2bccf93 ''Active sites, page 109, GCSE Combined Science Trilogy; Biology, CGP, AQA']
:[https://www.amazon.co.uk/gp/product/1782945954/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1782945954&linkCode=as2&tag=nrjc-21&linkId=100574c08fbbb64318256eb79ed61a76 ''Active sites, page 115, GCSE Biology, CGP, AQA']
:[https://www.amazon.co.uk/gp/product/1782945598/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1782945598&linkCode=as2&tag=nrjc-21&linkId=ad276ad49df77ab4b40ab4fd0fe09657 ''Active sites, page 25, GCSE Combined Science; The Revision Guide, CGP, AQA']
:[https://www.amazon.co.uk/gp/product/1782945563/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1782945563&linkCode=as2&tag=nrjc-21&linkId=9a1d023a374038e6072f33c4f3cf808b ''Active sites, page 28, GCSE Biology; The Revision Guide, CGP, AQA']
:[https://www.amazon.co.uk/gp/product/0198359373/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=0198359373&linkCode=as2&tag=nrjc-21&linkId=952a73bbb09d222ecc4b50d200679849 ''Active sites, page 42, GCSE Biology; Third Edition, Oxford University Press, AQA']
:[https://www.amazon.co.uk/gp/product/1471851354/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1471851354&linkCode=as2&tag=nrjc-21&linkId=9012a0d354024419214fb3ad5ac44ba0 ''Active sites, page 49, GCSE Combined Science Trilogy 1, Hodder, AQA']