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| style="height:20px; width:200px; text-align:center;" |This [[diagram]] shows an [[enzyme]] (the lock) and the [[substrate (Biology)|substrate]] (the key) fitting together. If the lock is '[[denaturation|denatured]]' the key no longer fits the lock and so the [[enzyme]] does not work.
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===References===
====Edexcel====
:[https://www.amazon.co.uk/gp/product/1782948120/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1782948120&linkCode=as2&tag=nrjc-21&linkId=dedef775c6a43dbb0a609441525adac0 ''Lock and key model, page 37, GCSE Biology, CGP, Edexcel '']
:[https://www.amazon.co.uk/gp/product/1292120193/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1292120193&linkCode=as2&tag=nrjc-21&linkId=572df39392fb4200db8391d98ae6314e ''Lock-and-key model of enzymes, page 15, GCSE Combined Science, Pearson Edexcel '']
:[https://www.amazon.co.uk/gp/product/1292120207/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1292120207&linkCode=as2&tag=nrjc-21&linkId=22455ff53961978667722edaa64c0be5 ''Lock-and-key model of enzymes, page 19, GCSE Biology, Pearson, Edexcel '']