Changes

: [[Mutation]]s affect [[Gene Expression|gene expression]]. Since [[gene]]s act as templates for building [[protein]], if a [[gene]] has been altered by [[mutation]] the [[protein]]s will also be changed.

: [[Mutation]]s lead to the [[protein]]s, [[Coding DNA|coded]] for by a [[gene]], to have a different shape and function. A [[mutation]] may cause the [[Active Site|active site]] of an [[enzyme]] to change, leading to a [[Substrate (Biology)|substrate]] no longer fitting in the [[Active Site|active site]] or, in rare cases, a different [[Substrate (Biology)|substrate]] fitting the [[Active Site|active site]].

===References===

:[https://www.amazon.co.uk/gp/product/1782945563/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1782945563&linkCode=as2&tag=nrjc-21&linkId=9a1d023a374038e6072f33c4f3cf808b ''Deletions (mutations), page 86, GCSE Biology; The Revision Guide, CGP, AQA '']

:[https://www.amazon.co.uk/gp/product/0008158770/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=0008158770&linkCode=as2&tag=nrjc-21&linkId=ec31595e720e1529e49876c3866fff6e ''Mutation, gene or cell, page 122, GCSE Physics; Student Book, Collins, AQA '']

:[https://www.amazon.co.uk/gp/product/1782945598/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1782945598&linkCode=as2&tag=nrjc-21&linkId=ad276ad49df77ab4b40ab4fd0fe10090 ''Mutations, page 73, GCSE Combined Science; The Revision Guide, CGP, AQA '']

:[https://www.amazon.co.uk/gp/product/0198359373/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=0198359373&linkCode=as2&tag=nrjc-21&linkId=952a73bbb09d222ecc4b50d200679849 ''Mutations, pages 78, 114, 206-207, 220-221, GCSE Biology; Third Edition, Oxford University Press, AQA '']

:[https://www.amazon.co.uk/gp/product/1782945563/ref=as_li_tl?ie=UTF8&camp=1634&creative=6738&creativeASIN=1782945563&linkCode=as2&tag=nrjc-21&linkId=9a1d023a374038e6072f33c4f3cf808b ''Mutations, pages 86, 95, GCSE Biology; The Revision Guide, CGP, AQA '']