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: The [[chemical]]s that an [[enzyme]] affects are called [[Substrate (Biology)|substrates]].
: [[Enzyme]]s have an area called an [[Active Site|active site]] which is where the [[enzyme]] interacts with the [[substrate]].
: The [[Active Site|active site]] is shaped to fit with only one [[Substrate (Biology)|substrate]] so [[enzyme]]s all have specific roles in an [[organism]].
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===Denaturation===
: [[Enzyme]]s can be [[denature]]d if the [[temperature]]s are too high or the [[pH]] is too extreme. Different [[enzyme]]s have a different [[Optimum|optimum]] [[temperature]] and [[Optimum|optimum]] [[pH]].
: When an [[enzyme]] is [[denature]]d it changes shape so that the [[substrate]] will no longer fit the [[Active Site|active site]].{| class="wikitable"|-|[[File:DenaturedEnzyme.png|center|400px]]|-| style="height:20px; width:200px; text-align:center;" |This [[diagram]] shows an [[enzyme]], [[Substrate (Biology)|substrate]] and the [[Active Site|active site]] of the [[enzyme]].|}
===pH and Enzymes===
: [[Enzyme]]s have an [[optimum]] [[pH]] at which they work best. If the [[pH]] is far from this [[optimum]] value the [[enzyme]] will [[denature]].